Dehydrogenases Requiring Nicotinamide Coenzymes by Jonathan Cecil


Dehydrogenases Requiring Nicotinamide Coenzymes by Jonathan Cecil

This book brings together lmportant work on the structure and function of the dehydrogenases requiring nicotinamide coenzymes. The structure and function of lactate dehydrogen- ase, alcohol dehydrogenase, and glyceraldehyde 3-phosphate dehydrogenase are compared. These are the relatively simple oligomeric dehydrogenases for which very extensive structural and mechanistic information is available. Kinetic studies are dealt with in general terms, with selected examples. Genetic and structural relationships revealed by primary structure are discussed. General features of the specificity of dehydrogen- ase reactions are described. The pyridine nucleotide - disulphide oxidoreductases exemplify a type of multicomponent enzyme complex. Lipoamide dehydrogenase, glutathione reductase, and thioredoxin reduct- ase are described and compared. The fatty acid synthesizing systems of some organ- isms are nonaggregated, whereas in other organisms they are multienzyme complexes containing, in animal tissues for example, two closely related multifunctional polypeptide chains. The dehydrogenase activities of the fatty acid syn- thesizing systems afford many points of interest, which are described and discussed. Hydroxymethylglutaryl-CoA reductase occupies a key position in the synthesis of isoprenoid compounds, including cholesterol. It probably occurs in all forms of life; in animal cells it is a microsomal enzyme. Its properties are reviewed.

About the Author

Other Formats

Book Info


276 pages


Jonathan Cecil
More books by Jonathan Cecil


Publication date

1st January 1980



I have told all my friends, family & teachers to see for themselves just how great the site is. Without fail, they are hugely impressed.

Alexander Boxall – age 11

Lovereading4kids is great, we get books really early never late. We love to read and review, and think you would like it too. The excitement

Jasmine Harris-Hart, age 12

It’s a community united by a passion for books and promoting the best there is in children’s literature.

Sam Bateman and family

We love Lovereading as my 5 year old loves to read new books before anyone else has a chance, she says it makes reading exciting!

Tracey Chorley

I love lovereading4kids because I’ve read amazing books I would never have picked up, and its opened doors to new genre’s I now love.

Harriet Cunningham

It’s really exciting to read and review new books, thrilling to see my reviews online and I love finding the final published copies on sale.

Sam Harper – age 10

I love Lovereading4kids because I get an opportunity to put my opinion forward and to try new books

Elosie Clarkson – age 11

I think Lovereading4kids is an amazing company because of the friendly staff and the fabulous chance to read great books before publication.

Adam Graham

Lovereading 4 schools